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KMID : 0613820060160060989
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Journal of Life Science
2006 Volume.16 No. 6 p.989 ~ p.993
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Antimicrobial Activity of the Extract from Pyrola japonica against Bacillus subtilis
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Park Hae-Gun
Cha Mi-Ran
Hwang Ji-Hwan
Kim Ju-Young
Park Mi-Suk
Choi Sun-Uk
Park Hae-Ryong
Hwang Yong-Il
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Abstract
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The antimicrobial substance from Pyrola japonica were extracted and isolated. Eighty percent ethanol extract of dried Pyrola japonica was fractionated to hexane, diethyl ether, ethyl acetate and aqueous layer. The hexane-soluble fraction showed the highest inhibitory activity against Bacillus subtilis. Moreover the hexane layer was fractionated into 5 groups by silica gel column chromatography. From the results, group No. 2 (18~40 fractions) showed the highest antimicrobial activity. The group was re-separated to 10 fractions by preparative thin layer chromatography and the peak Ⅰ as active fraction was isolated by HPLC.
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KEYWORD
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Antimicrobial activity, Pyrola japonica, hexane fraction, Bacillus subtilis
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